Combined effects of <i>Spirulina platensis</i> and <i>Pediococcus acidilactici</i> on the growth performance, digestive enzyme activity, antioxidative status, and immune genes in zebrafish

Abstract The combined effects of Spirulina platensis (SP) and Pediococcus acidilactici (PA) on growth performance, digestive enzyme activity, antioxidative status, immune genes in zebrafish were investigated the present study. Four experimental diets designed: control three test mixed with SP at 2.5%, PA 10 7 CFU/g, or a combination 2.5% CFU/g PA. After 56 days, fish treated mixture had higher final weight, weight gain, SGR, lower FCR than fed (P&lt;0.05). results also illustrated that PA, SP, their (P&lt;0.05) protease amylase activities control. lipase activity was significantly alternative complement pathway (ACH50) lysozyme mucus samples both diets. total immunoglobulin level skin In body homogenates samples, levels markedly dietary diet improved glutathione peroxidase, superoxide dismutase, capacity. expression IL-1β IL-8 Fish marked upregulation gene expression. conclusion, S. P. is more effective using each individually for improving capacity zebrafish.